Publications

Dr. Karl-Heinz Ott  ottk@expertbioinformatics.com

  1. Aranibar, N., Bennett, J., Tomlinson, L., Horvath, J., Tirmenstein, M., Cosma, G., Ott, K-H. Progressive Muscle Toxicity and Evidence of Mitochondrial Dysfunction in Dogs Treated with Ibipinabant, a Cannabinoid-1 Receptor Antagonist. Submitted to Archives of toxicology, 2011
  2. Ji, R., Ott, K-H., Yordanova, R., and Bruccoleri, R. FDR-FET – an optimizing gene set enrichment analysis method accepted at Advances and Applications in Bioinformatics and Chemistry, 2011
  3. Tomlinson, L., Tirmenstein, M., Janovitz, E., Aranibar, N., Ott, K-H., Bennett, M., Kozlosky, J., Patrone, L., Moyer, C., Achanzar, W., Augustine, K., Brannen, K., Carlson, K., Charlap, J., Dubrow, K., Kang, L., Marthaler, L., Panzica, J., Flint, O., Moulin, F., Zhang, H., Cosma , G. Non-Pharmacology-Based CB-1 Antagonist-Induced Striated Muscle Toxicity and Ethylmalonic-Adipic Aciduria in Beagle Dogs in preparation
  4. Ott, K-H., Aranibar, N., Van Vleet, T., Cantor, G., Waites, C., Dominick, M: Metabolomics Analysis of Young and Aged Rats Treated with Muraglitazar, a PPAR Agonist. Submitted to J. Appl. Tox., 2010
  5. Aranibar, N., Bhaskaran ,V., Ott, K-H., Vassallo, J., Nelson, D., Lecureux, L., Gong, L., Stryker, S., Lehman-McKeeman, L. Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling Mag. Res. Chem. Dec;47 Suppl 1:S12-9, 2009
  6. Ji, R., de Silva, H., Jin, Y., Bruccoleri, R., Cao, J., He, A., Huang, W.,  Kayne, P., Neuhaus, I., Ott, K-H., Penhallow, B., Cockett, M., Neubauer, M., Siemers, N., Ross-Macdonald, P. Transcriptional Profiling of the Dose Response: A More Powerful Approach for Characterizing Drug Activities. PLoS Comput Biol 5(9): 2009
  7. Warrack, B., Hnatyshyn, S., Ott, K-H., Reily, M., Sanders, M., Zhang, H., Drexler, D. “Normali­zation Strategies for Metabonomic Analysis of Urine Samples”. J. Chromatography B, 877, 547, 2009
  8. Ott, K-H., Araníbar, N.  “Metabonomics in Discovery and Development. ” From: Methods in Molecular Biology, vol. 358: Metabolomics: Methods and Protocols Edited by: W. Weckwerth Humana Press Inc., Totowa, NJ.  2006
  9. Aranibar, N., Ott, K-H., Roongta, V., Mueller, L.: “Metabolomic analysis using optimized NMR and statistical methods”. Analytical Biochemistry, 355, 62-70, 2006
  10. Ott, K-H., “Summary of Advances in Metabolic Profiling,” London, 2006. Thomson Int. Investigational Drugs Database (IDdb)  2006
  11. Ott, K-H., Araníbar, N., Singh, B., Stockton, G. W.  “Metabonomics classifies pathways affected by bioactive compounds.” Phytochemistry, 62, 971-983,  2003.  (100 citations)
  12. Ott, K-H., Kwagh, J. G., Stockton, G. W., Sidorov, V., and Kakefuda, G. “Rational Design of Herbicide Resistant Crops by Structure Modeling and Site-Directed Mutagenesis of Acetohydroxyacid Synthase”, Journal of Molecular Biology, 1996, 263(2), 359-368.  (Over 60 citations)
  13. Ott, K-H. and Meyer, B.  “Parametrization of the GROMOS Force Field for Oligosaccharides and Assessment of the Efficiency of Molecular Dynamics Simulations”,
    Journal of Computational Chemistry, 1996, 17(8), 1068-1084. (over 30 citations)
  14. Ott, K-H. and Meyer, B.  “Molecular Dynamics Simulations of Maltose in water”.
    Carbohydrate Research, 1996, 281, 11-31. (over 30 citations)
  15. Pieper, J., Ott, K-H., and Meyer, B. “Stabilization of the T1 Fragment of Glycophorin AN Through Interactions with N- and O-linked Glycans”, Nature Structural Biology, 1996, 3(3), 228-232.
  16. Ott, K-H., Rüterjans, H.  “Solution Structure of the LexA Operator Sequence”,
    Quarterly of Magnetic Resonance in Biology and Medicine, 1995, II(3) 195-208.
  17. Ott, K-H., Rüterjans, H.  “The Structure and Dynamics of the LexA Recognition Sequence.  A MD Study Based on NMR Data.”,
    Quarterly of Magnetic Resonance in Biology and Medicine, 1995, II(3), 209-224.
  18. Ott, K-H., Becker, S., Gordon, R. D., and Rüterjans, H. “Solution Structure of m-Conotoxin GIIIA Analyzed by 2D-NMR and Distance Geometry Calculations“,
    FEBS Letters, 1991, 278:160-166.
  19. Ott, K-H. “Solution Conformations of the SOS Operators of E. coli using NMR Spectroscopy and Molecular Dynamics Simulations”, Ph.D. Thesis, University of Frankfurt, Germany, 1991.
  20. Ott, K-H. “NMR Investigations of Oligonucleotides”, Diploma Thesis, University of Frankfurt, Germany, 1987.